Enhancing the QUAlity and Transparency Of health Research

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Quality of reporting of randomised controlled trials in oncology

The selected references below highlight current issues with the quality of reporting of randomised controlled trials in oncology publications. All 20 reviews used the CONSORT statement to assess quality of reporting and address different aspects of research reporting within specific disease areas or more generally across all oncology specialties.


Ah-See KW, Molony NC. A qualitative assessment of randomized controlled trials in otolaryngology. J Laryngol Otol. 1998;112(5):460-463. PMID: 9747475

Bylicki O, Gan HK, Joly F, Maillet D, You B, Peron J. Poor patient-reported outcomes reporting according to CONSORT guidelines in randomized clinical trials evaluating systemic cancer therapy. Ann Oncol. 2015;26(1):231-237. PMID: 25355720

Carlton DA, Kocherginsky M, Langerman AJ. A systematic review of the quality of randomized controlled trials in head and neck oncology surgery. Laryngoscope. 2015;125(1):146-152. PMID: 24729155

Cherny NI, Abernethy AP, Strasser F, Sapir R, Currow D, Zafar SY. Improving the methodologic and ethical validity of best supportive care studies in oncology: lessons from a systematic review. J Clin Oncol. 2009;27(32):5476-5486. PMID: 19564538

Guo JW, Sward KA, Beck SL, Staggers N. Quality of reporting randomized controlled trials in cancer nursing research. Nurs Res. 2014;63(1):26-35. PMID: 24335911

Hui D, Arthur J, Dalal S, Bruera E. Quality of the supportive and palliative oncology literature: a focused analysis on randomized controlled trials. Support Care Cancer. 2012;20(8):1779-1785. PMID: 21935717

Kober T, Trelle S, Engert A. Reporting of randomized controlled trials in Hodgkin lymphoma in biomedical journals. J Natl Cancer Inst. 2006;98(9):620-625. PMID: 16670387

Lai R, Chu R, Fraumeni M, Thabane L. Quality of randomized controlled trials reporting in the primary treatment of brain tumors. J Clin Oncol. 2006;24(7):1136-1144. PMID: 16505433

Lee CW, Chi KN. The standard of reporting of health-related quality of life in clinical cancer trials. J Clin Epidemiol. 2000;53(5):451-458. PMID: 10812316

Lu L, Liao M, Zeng J, He J. Quality of reporting and its correlates among randomized controlled trials on acupuncture for cancer pain: application of the CONSORT 2010 Statement and STRICTA. Expert Rev Anticancer Ther. 2013;13(4):489-498. PMID: 23560843

Pat K, Dooms C, Vansteenkiste J. Systematic review of symptom control and quality of life in studies on chemotherapy for advanced non-small cell lung cancer: how CONSORTed are the data? Lung Cancer. 2008;62(1):126-138. PMID: 18395928

Peron J, Maillet D, Gan HK, Chen EX, You B. Adherence to CONSORT adverse event reporting guidelines in randomized clinical trials evaluating systemic cancer therapy: a systematic review. J Clin Oncol. 2013;31(31):3957-3963. PMID: 24062406

Peron J, Pond GR, Gan HK, Chen EX, Almufti R, Maillet D, You B. Quality of reporting of modern randomized controlled trials in medical oncology: a systematic review. J Natl Cancer Inst. 2012;104(13):982-989. PMID: 22761273

Peron J, You B, Gan HK, Maillet D, Chen EX, Pond GR. Influence of statistician involvement on reporting of randomized clinical trials in medical oncology. Anticancer Drugs. 2013;24(3):306-309. PMID: 23221738

Rothenberger LG, Henschel AD, Schrey D, Becker A, Boos J. Methodological and ethical aspects of randomized controlled clinical trials in minors with malignant diseases. Pediatr Blood Cancer. 2011;57(4):599-605. PMID: 21548015

Sebastian M, Schmittel A, Reck M. First-line treatment of EGFR-mutated nonsmall cell lung cancer: critical review on study methodology. Eur Respir Rev. 2014;23(131):92-105. PMID: 24591666

Sut N, Senocak M, Uysal O, Koksalan H. Assessing the quality of randomized controlled trials from two leading cancer journals using the CONSORT statement. Hematol Oncol Stem Cell Ther. 2008;1(1):38-43. PMID: 20063527

Toulmonde M, Bellera C, Mathoulin-Pelissier S, Debled M, Bui B, Italiano A. Quality of randomized controlled trials reporting in the treatment of sarcomas. J Clin Oncol. 2011;29(9):1204-1209. PMID: 21321290

Zhang S, Liang F, Li W, Hu X. Subgroup Analyses in Reporting of Phase III Clinical Trials in Solid Tumors. J Clin Oncol. 2015;33(15):1697-1702. PMID: 25897150

Ziogas DC, Zintzaras E. Analysis of the quality of reporting of randomized controlled trials in acute and chronic myeloid leukemia, and myelodysplastic syndromes as governed by the CONSORT statement. Ann Epidemiol. 2009;19(7):494-500. PMID: 19523596