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07/12/2023 Consensus Statement for Protocols of Factorial Randomized Trials: Extension of the SPIRIT 2013 Statement 24/10/2023 Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance 04/01/2023 Guidelines for Reporting Outcomes in Trial Protocols: The SPIRIT-Outcomes 2022 Extension 01/10/2021 Guidelines for cellular and molecular pathology content in clinical trial protocols: the SPIRIT-Path extension 22/06/2021 Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement 09/09/2020 Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI Extension 28/02/2020 Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018: Recommendations, Explanation and Elaboration (SPIRIT-TCM Extension 2018) 28/02/2020 SPIRIT extension and elaboration for n-of-1 trials: SPENT 2019 checklist 07/02/2018 Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols: The SPIRIT-PRO Extension

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