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28/02/2020 SPIRIT extension and elaboration for n-of-1 trials: SPENT 2019 checklist 07/02/2018 Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols: The SPIRIT-PRO Extension 14/05/2017 SPIRIT 2013 Statement: Defining standard protocol items for clinical trials 18/03/2016 Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers

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